Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Impaired splenic function in long-term survivors of childhood cancer; diagnostic and therapeutic strategies.

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Impaired splenic function in long-term survivors of childhood cancer; diagnostic and therapeutic strategies. - DCOG LATER Q2008 - spleen

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47549

Enrollment

469

Registered

2016-12-09

Start date

2017-10-25

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

impaired splenic function in long-term survivors of childhood cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: Inclusion of all survivors aged >=18 years, after 1) splenectomy, 2) irradiation over the spleen and 3) total body irradiation

Exclusion criteria

Exclusion criteria: diagnosis of childhood cancer with survival less than 5 years, age at diagnosis >17 years or diagnosis while residing in foreign country, survivors who are not capable of giving informed consent

Design outcomes

Primary

Measure	Time frame
• Individual diagnostic value of IgM memory B cells after irradiation over the spleen. • The number of hypo- or asplenic patients with vaccine failure.	—

Secondary

Measure	Time frame
• Duration of protection after pneumococcal vaccination. • The number of survivors with hyposplenism after irradiation over the spleen related to the dose of irradiation and time interval from irradiation assessed by the number of IgM memory B-cells. .	—

Countries

Netherlands

Outcome results