Non-resolving acute respiratory insufficiency in mechanically ventilated patients
Conditions
Interventions
Acute respiratory insufficiency
Confocal Laser Endomicroscopy
Mechanically ventilated patients
Optical Coherence Tomography
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - *18 years of age - Admitted to the intensive care unit of the Academic Medical Center - Non-resolving acute respiratory failure mandating a standard diagnostic bronchoscopy with broncho-alveolar lavage
Exclusion criteria
Exclusion criteria: - Inability and willingness to provide informed consent by family-members - Inability to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Assessing technical feasibility of pCLE and OCT of various (diseased/non-diseased on HR-CT-scan) alveolar compartments in mechanically ventilated patients. (% of successful videos/time for procedure (min)) - Assessing procedure-related adverse events of pCLE and OCT | — |
Secondary
| Measure | Time frame |
|---|---|
| - To compare the pCLE/OCT imaging with the radiological patterns - To compare the pCLE/OCT-imaging with the histopathology (where available) | — |
Countries
The Netherlands
Outcome results
None listed