The effect of Glucocorticoid Receptor Polymorphisms and Metabolically Active Genetic Variants on Glucose Metabolism in the Skeletal Muscle

The effect of Glucocorticoid Receptor Polymorphisms and Metabolically Active Genetic Variants on Glucose Metabolism in the Skeletal Muscle - GR polymorphisms, metabolic genetic variants and insulin resistance

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47510

Enrollment

447

Registered

2012-10-19

Start date

2014-07-09

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes insulin resistance

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Subjects selected from studies 09-3-033; 07-3-028; 04-257; 03-015; 06-3-038; 09-3-039; 11-3-092; 11-2-003; 13-3-058; 13-2-030; 15-3-030; 113003; 153046; 163019; 163052; 173008; 173017; 173021; 173024; 173031; 173037; 183001 and 183006 (n=447).

Exclusion criteria

Exclusion criteria: NA, these already have been set by the previous studies.

Design outcomes

Primary

Measure	Time frame
New study outcome parameter: - profile of GC-polymorphisms - genetic variants influencing energy-metabolism Study outcome parameters (already obtained): -Body composition (underwater weighing) -Insulin sensitivity (hyperinsulinemic-euglycemic clamp) -Substrate oxidation (indirect calometry during the clamp) -Skeletal muscle oxidative capacity -VO2max-test -Skeletal muscle lipid accumulation in muscle biopsies.	—

Measure

Time frame

New study outcome parameter: - profile of GC-polymorphisms - genetic variants influencing energy-metabolism Study outcome parameters (already obtained): -Body composition (underwater weighing) -Insulin sensitivity (hyperinsulinemic-euglycemic clamp) -Substrate oxidation (indirect calometry during the clamp) -Skeletal muscle oxidative capacity -VO2max-test -Skeletal muscle lipid accumulation in muscle biopsies.

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Countries

Netherlands

Outcome results