Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Hyposalivation in long-term survivors of pediatric cancers following different treatment regiments.

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek: Hyposalivation in long-term survivors of pediatric cancers following different treatment regiments. - SKION LATER Q2008 - SALI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47501

Enrollment

300

Registered

2015-05-08

Start date

2016-05-04

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dry mouth xerostomia

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients who were treated for childhood cancer (before age 18) in one of the Pediatric Oncology Centers between 1960 and 2001 and who survived for at least 5 years after diagnosis will be included in the SKION LATER study. Participating centres are located in Amsterdam (VU University Medical Center (VUMC)), Groningen (Children's Cancer Center/ University Medical Center Groningen (UMCG)), Rotterdam (Rotterdam Erasmus MC-Sophia (REMC-S), Nijmegen (University Medical Center Nijmegen (UMCN)), Leiden (Leiden University Medical Center (LUMC) and Utrecht (Princess Máxima Center for Pediatric Oncology (PMC)). From this cohort, 300 childhood cancer survivors (100 who received irradiation to head or neck, 100 with a history of chronic graft versus host disease and 100 treated with chemotherapy but not with radiotherapy) will be asked to participate in the salivary study

Exclusion criteria

Exclusion criteria: diagnosis of childhood cancer with survival less than 5 years, age at diagnosis >17 years or diagnosis while residing in foreign country

Design outcomes

Primary

Measure	Time frame
- reduced unstimulated and stimulated salivary flow and Patient Reported Outcomes indicative for xerostomia - association between salivary flow measurements and complaints indicative for xerostomia - patient and therapy related risk factors for hyposalivation and xerostomia - association between xerostomia and oral-health-related quality of life - selected microorganisms and markers related to disease, oral function and defense mechanisms in oral fluid samples.	—

Measure

Time frame

- reduced unstimulated and stimulated salivary flow and Patient Reported Outcomes indicative for xerostomia - association between salivary flow measurements and complaints indicative for xerostomia - patient and therapy related risk factors for hyposalivation and xerostomia - association between xerostomia and oral-health-related quality of life - selected microorganisms and markers related to disease, oral function and defense mechanisms in oral fluid samples.

—

Countries

Netherlands

Outcome results