viral infection of the heart viral myocarditis
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In the viral myocarditis group patients will be included when they are mentally competent and when they present with suspected viral myocarditis (show flu-like symptoms combined with acute loss of heart function) and comply to the ESC/ACC position statement for endomyocardial biopsy. In the AMI group (controls) patients will be included when they are mentally competent and present with an acute myocardial infarction. Because viral myocarditis can mimic AMI, we will also include patients who present with infarct-like complaints, but show non-occluded epicardial coronary arteries with coronary angiography. Based on subsequent MRI analyses, these patients will later be subdivided into the AMI group (in case of myocardial infarction with non-occluded coronary arteries (MINOCA)) or the viral myocarditis group.
Exclusion criteria
Exclusion criteria: In the viral myocarditis group the main exclusion criteria are: acute myocardial infarction, prednisolon use or fear of MRI. In the AMI group the main exclusion criteria are to suffer from a viral infection (including HIV). In both groups prednisolon use and mental incompetence is an exclusion cirteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| De primary study parameters are the differences in biomarker profile (in heart, blood and skeletal muscle) between viral myocarditis (and the potential subgroups within this group) and acute myocardial infarction patients, as well as the determination of virus type and titer in relation to the pathophysiology of these (sub)groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed