optic chiasm compression
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * > 18 years * At least one impaired central endocrine axis * Clearly documented cause of hypopituitarism * Adequate replacement of hormone deficiencies * Patients with history of chiasm compression: documentation of visual field defects or loss of visual acuity and a suprasellar extending tumour on MRI (before treatment)
Exclusion criteria
Exclusion criteria: * Ocular pathology that could influence the PIPR * Impaired colour vision * Previous intra-ocular surgery * Hypersensitivity to tropicamide * Use of medicinal eye drops or systemic medication that can affect the pupillary response; assessed on an individual basis * Pituitary surgery 3 time zones the month prior to examination * Pregnancy * Other comorbidity that could interfere with the study procedures; assessed on an individual basis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in PIPR after a blue-light stimulus between the two groups; expressed in two parameters: - PIPR-mm = baseline pupil diameter (mm) * post-blue pupil diameter (mm) - PIPR-% = 100 x PIPR-mm/baseline pupil diameter (mm) | — |
Secondary
| Measure | Time frame |
|---|---|
| * Differences in questionnaire results on sleep quality, chronotype, fatigue and depression (MCTQ, HDSQ, PSQI, ESS, ISI, BQ, MFI-20, HADS) * Differences in polysomnography, actigraphy & sleep diary results * Differences in skin temperature results * Correlations between parameters of PIPR, sleep, sleep-wake rhythm and skin temperature | — |
Countries
Netherlands
Outcome results
None listed