Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis

Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis - Mealworm protein

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON47452

Enrollment

Registered

2016-11-09

Start date

2018-03-13

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

muscle growth Muscle protein synthesis

Interventions

From p17 of C1 protocol document: Subjects will perform unilateral resistance exercise and consume either 30 g mealworm or milk protein. In addition, continuous intravenous tracer infusions will be

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Healthy males * Age between 18 and 35 y inclusive * BMI between 18.5 and 30 kg/m2

Exclusion criteria

Exclusion criteria: * Use of tobacco products * Non-steroidal anti-inflammatory drugs (NSAID) in the 4 days prior to the experimental trial * Allergies to milk proteins (whey or casein) * Allergies to house dust mites or crustaceans * Lactose intolerance * Phenylketonuria (PKU) * Blood donation within 2 months of study initiation * Arthritic conditions * A history of neuromuscular problems * Previous participation in amino acid tracer studies * Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications) * Diabetes * Training more than 5 days per week

Design outcomes

Primary

Measure	Time frame
From p23 of C1 protocol document: The main study endpoint is the fractional synthetic rate (FSR) of muscle protein synthesis (myofibrillar proteins) from 0-5 hours in the post-prandial period.	—

Secondary

Measure	Time frame
From p23 of C1 protocol document: * The fractional synthetic rate (FSR) of muscle protein synthesis (myofibrillar proteins) from -3-0, 0-2 and 2-5 hours in the postabsorptive and post-prandial period respectively. * Plasma free phenylalanine enrichment (expressed as MPE) * Plasma free tyrosine enrichment (expressed as MPE) * Plasma total phenylalanine (expressed as mol/L) Plasma total tyrosine (expressed as mol/L) Total plasma amino acids (AAmax [mol/L]) Plasma glucose (glucosemax [mmol/L]) * Plasma insulin (insulinmax [mU/L]) * Plasma total phenylalanine, leucine and tyrosine concentrations (expressed as *mol/L)	—

Measure

Time frame

From p23 of C1 protocol document: * The fractional synthetic rate (FSR) of muscle protein synthesis (myofibrillar proteins) from -3-0, 0-2 and 2-5 hours in the postabsorptive and post-prandial period respectively. * Plasma free phenylalanine enrichment (expressed as MPE) * Plasma free tyrosine enrichment (expressed as MPE) * Plasma total phenylalanine (expressed as *mol/L) * Plasma total tyrosine (expressed as *mol/L) * Total plasma amino acids (AAmax [*mol/L]) * Plasma glucose (glucosemax [mmol/L]) * Plasma insulin (insulinmax [mU/L]) * Plasma total phenylalanine, leucine and tyrosine concentrations (expressed as *mol/L)

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)