joint degeneration osteoarthritis
Conditions
Interventions
joint fluid
joint homeostasis
knee distraction
knee osteoarthrits
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients with knee joint degeneration (osteoarthritis) eligible in regular clinical practice for knee joint distraction. For the study specific: written IC based on PIF for 3 intra-articular joint fluid needle aspirations.
Exclusion criteria
Exclusion criteria: Unable to undergo knee joint distraction in regular clinical practice. For the study specific exclusion criteria: unable to provide written IC based on written (PIF) and oral study information for 3 intra-articular joint fluid needle aspirations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in joint homeostasis. Joint homeostasis is a complex of soluble mediators and cells responsible for the integrity (e.g. nutrition, maintenance, and turnover) of the cartilage tissue (note: cartilage is not vascularised and thus for its mediators dependent on exchange with the joint fluid). There will be a focus on changes in i) growth factors, ii) proteases, iii) proinflammatory cytokines, iv) pro-inflammatory cells, and v) stem cells. | — |
Countries
The Netherlands
Outcome results
None listed