Measurement of Mean Systemic Filling Pressure & Stressed Volume with CardioQ+® Oesophageal Doppler Measurement

Measurement of Mean Systemic Filling Pressure & Stressed Volume with CardioQ+® Oesophageal Doppler Measurement - Measurement of MSFP & stressed volume with CardioQ+®

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47434

Enrollment

Registered

2016-12-20

Start date

2017-05-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geavanceerde hemodynamische monitoring bij hemodynamische instabiliteit obv verschillende oorzaken zoals cardiogene shock, etc. Hemodynamic instability shock

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients planned for elective CABG surgery - Aged 18 years and over - Being able to give written informed consent prior to surgery

Exclusion criteria

Exclusion criteria: - A contraindication for fluid loading (700ml) assessed by the treating ICU physician. - Pregnancy - Morbid obesity (BMI >40) - Major hemodynamic instability with a mean arterial pressure (MAP)

Design outcomes

Primary

Measure	Time frame
In this study fluid loading responsiveness after 500 mL fluid, and stressed volume measurement before and after 500 mL fluid administration are the main outcome measures.	—

Secondary

Measure	Time frame
Stressed volume is calculated from mean systemic filling pressure (MSFP). Previous studies have shown it is possible to measure MSFP with the MSFParm method, However they describe limitations [Geerts] and it is not well established how accurate this method is. If the MSFParm method would be as reliable in assessing stressed volume as the MSFPhold method this would be clinically relevant since the MSFParm method is not restricted to mechanically ventilated sedated patients. The MSFParm method could potentially be used in all ICU patients with an arterial line. In this study, aside from patient demographics and surgical procedure statistics we will document MAP, SBP, DBP, PPV, SV, SVV, COdoppler, COpulsecontour, HR, central temperature, Vs, Csys and MSFP, as well as wave reflection parameters (augmentation index, reflection magnitude) determined using FloTrac/Vigileo (Edwards Lifesciences). Paired measurement will be performed before and after the fluid challenge. At steady state, 1-2 minutes clean signal collection will be recorded, before and after the fluid challenge. Kinetic energy will be calculated from SV, Peak velocity and Mean acceleration (Peak velocity/ Flow time to peak velocity). Afterload parameters of elastance, resistance and inertia will be calculated from Flow time to peak, Pressure at peak flow, Flow time (FT), not corrected for HR, End systolic pressure (Pressure at FT), Diastolic pressure, Peak Velocity, Mean acceleration.	—

Measure

Time frame

Stressed volume is calculated from mean systemic filling pressure (MSFP). Previous studies have shown it is possible to measure MSFP with the MSFParm method, However they describe limitations [Geerts] and it is not well established how accurate this method is. If the MSFParm method would be as reliable in assessing stressed volume as the MSFPhold method this would be clinically relevant since the MSFParm method is not restricted to mechanically ventilated sedated patients. The MSFParm method could potentially be used in all ICU patients with an arterial line. In this study, aside from patient demographics and surgical procedure statistics we will document MAP, SBP, DBP, PPV, SV, SVV, COdoppler, COpulsecontour, HR, central temperature, Vs, Csys and MSFP, as well as wave reflection parameters (augmentation index, reflection magnitude) determined using FloTrac/Vigileo (Edwards Lifesciences). Paired measurement will be performed before and after the fluid challenge. At steady state, 1-2 minutes clean signal collection will be recorded, before and after the fluid challenge. Kinetic energy will be calculated from SV, Peak velocity and Mean acceleration (Peak velocity/ Flow time to peak velocity). Afterload parameters of elastance, resistance and inertia will be calculated from Flow time to peak, Pressure at peak flow, Flow time (FT), not corrected for HR, End systolic pressure (Pressure at FT), Diastolic pressure, Peak Velocity, Mean acceleration.

—

Countries

Netherlands

Outcome results