chronic allograft dysfunction 'interstitial fibrosis and tubular atrophy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group A (n=15): Patients have undergone at least one kidney transplantation procedure;Patients are 18 year or older;Patients are currently suspect for CAD at the time of inclusion (CAD is defined as a clinical diagnosis characterized by deterioration of kidney function in any way (e.g. increase in SCr, new proteinuria) that demands further diagnostic evaluation; Kidney biopsy is performed according to the existing guidelines for clinical practice just prior to or shortly after the MRI-scan has been performed (time in between the events
Exclusion criteria
Exclusion criteria: Volunteers with contra-indications for MRI (like a pacemaker, an internal prosthesis or claustrophobia); Refusal of volunteers to be informed of chance findings possibly relevant to their health; Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint will be the degree of functional allograft damage. Differences between values of various MRI parameters (see *5.2 Study Procedures*) obtained in transplantation patients with and without chronic allograft dysfunction on the one hand, and between transplantation patients and healthy (control) volunteers on the other hand, will be analyzed. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint will be the degree of structural allograft damage. This degree will be determined by analyzing the correlation between the best parameter (or combination of parameters) and the degree of IF/TA that was diagnosed in patients included in group A. Reproducibility of the scan protocol in patients. | — |
Countries
Netherlands
Outcome results
None listed