Prospective and cross-sectional multicentre cohort study nerve sonography in polyneuropathy

Prospective and cross-sectional multicentre cohort study nerve sonography in polyneuropathy - PROZEP

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47420

Enrollment

350

Registered

2013-09-12

Start date

2015-02-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

generalised disease of the nerves

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: high clinical suspicion of polyneuropathy (based on history and findings at neurological examination), age 18- 80 years.

Exclusion criteria

Exclusion criteria: age 80 years, prior history of polyneuropathy, physically unable to undergo electrodiagnostic or HRUS of the peripheral nervous system (e.g. cast, recent pelvic fracture or prosthetic operation, extensive reconstructive surgery on the extremities).

Design outcomes

Primary

Measure	Time frame
Sonographic neural abnormalities (nerve hypertrophy, fascicle enlargement and hypervascularisation), clinical findings (ie pattern and degree of sensory disturbance and muscle weakness (medical research council (MRC) sum-score), results of electrodiagnostic studies, laboratory and CSF analysis, treatment response in treated cases, nerve biopsy, family history and DNA analysis.	—

Countries

Netherlands

Outcome results