gout Gouty arthritis
Conditions
Interventions
None listed
Sponsors
Huisartsgeneeskunde
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age: older than 18 years. - Contacted their GP with a gout attack in the year 2013, 2014 or 2015
Exclusion criteria
Exclusion criteria: - Patients with a limited life expectancy. - Patients that are not able (independently or with help) to fill in the Dutch questionnaires.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoints are the frequency of gout attacks, the presence of tophi and the use of Allopurinol. The presence of gout will be validated according to the ACR-EULAR 2015 criteria for gout and the gout calculator. The frequency and characteristics of gout attacks will be measured using the modified Gout Assessment Questionnaire 2.0. The presence and burden of tophi will be measured using the validated Tophus Impact Questionnaire (TIQ-20). The use of allopurinol will be ascertained using the Brief Medication Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Demographics measured at baseline using questions derived from the Medical Consumption Questionnaire. 2. Tests include the following laboratory examinations: estimated glomerular filtration rate (eGFR), uric acid level, total cholesterol, low- and high-density-lipoproteïne cholesterol and glucose (fasting). Therefore, at baseline a single venapunction will take place at baseline. Blood pressure will be measured once at baseline. 3. Clinical factors: Comorbidity will be assessed at baseline, 1 year and 2 years FU using the Self-Administered Comorbidity Questionnaire. For calculating BMI, at baseline the patients length and weight will be asked. Physical and mental health will be determined at baseline, 1 year and 2 years using the SF-36 physical and mental component summary [18] and quality of life via the EQ-5D. 4. Medication: The use and adherence to allopurinol and other gout-medication will be evaluated every 3 months. The adherence to prescribed medication and over the counter medication will be measured at baseline, 1 year and 2 years follow-up using a derived version of the Brief Medication Questionnaire. 5. Diet and lifestyle: Dietary intake (consumption of fructose-rich and carbonated beverages, alcohol, purine rich food, lactose and dairy products) will be measured using the Dutch validated Food Frequency Questionnaire, at baseline, 1 and 2 years follow-up. Physical activity will be measured at baseline and hereafter every 6 months with the International physical activity questionnaire. Smoking status will be asked at baseline, 1 year and 2 years follow-up. | — |
Countries
Netherlands
Outcome results
None listed