Is post-ictal EEG suppression (PGES) in epilepsy caused by excessive cortical inhibition? Pilot study

Is post-ictal EEG suppression (PGES) in epilepsy caused by excessive cortical inhibition? Pilot study - Post-ictal EEG suppression and inhibition

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47409

Enrollment

Registered

2019-02-12

Start date

2017-05-08

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy seizures

Interventions

Epilepsy

Post-Ictal Generalised EEG suppression (PGES)

Sudden Unexpected Death in Epilepsy (SUDEP)

Transcranial Magnetic Stimulation (TMS)

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Cases - Aged 18 years or over - Frequent convulsive seizures (*1 per 12 months) - Recurring nocturnal seizures Controls - Aged 18 years or over - No epilepsy

Exclusion criteria

Exclusion criteria: Cases and controls - Pregnancy - Use or medication other than anti-epileptic drugs that alter cortical excitability (b-blockers) - performance IQ

Design outcomes

Primary

Measure	Time frame
TMS measures of cortical excitability (Motor threshold, Motor evoked potential amplitude, cortical silent period, short and long recovery curves).	—

Secondary

Measure	Time frame
Serum levels of anti-epileptic medication	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)