Hypertension High Blood Pressure
Conditions
Interventions
The intervention group will be treated using SPRINT-targets (SBP *120mmHg) and
the control group using conventional blood pressure targets (SBP
Cerebral Bloof Flow (CBF)
Cerebral Small Vessel disease (CSVD)
Hemodynamics
Hypertension
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - * 65 years of age - High systolic blood pressure of 150-200 mmHg assessed with a daytime 24-hour BP (with or without taking antihypertensive medication) - Cerebral small vessel disease (white matter lesions; Fazekas score * 2) on MRI
Exclusion criteria
Exclusion criteria: - Diabetes mellitus - Experienced myocardial infarction within the past 12 months - Medical history of stroke in the past 6 months or large (sub) cortical cerebral infarction on MRI - Medical history of end stage heart failure (NYHA III-IV) - Stage 4-5 kidney failure - Clinical Dementia Rating (CDR) scale>1 - Life expectancy less than 1 year - Unable to obtain an optimal window for TCD measurements - Significant stenosis (>70%) of the left of right common carotid artery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures are: CBF (static and dynamic) velocity measured with Transcranial Doppler (TCD). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are: cognitive functioning, degree of white matter lesions. orthostatic hypotension, cerebral autoregulatory capacity, CO2 responsiveness, premature trial termination because of unacceptable drug side effects. | — |
Countries
The Netherlands
Outcome results
None listed