Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij een verandering in de functie van de HPA-as optreedt. Not applicable
Conditions
Interventions
In the experimental group, cortisol is elevated exogenously on three
consecutive days by administration of 100 mg hydrocortisone.
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy, female, premenopausal, 18-30 years of age
Exclusion criteria
Exclusion criteria: Somatic and/or psychiatric diseases, symptoms of infection, use of medication (including oral contraceptives), recent major stressful life events
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the AUCg of cortisol during rest in the evocation phase. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are the AUCg of cortisol during exposure to a validated short-term psychosocial stress task, as well as the autonomic parameters alpha-amylase, heart rate, and skin conductance, and the psychological parameter self-reported well-being during the evocation phase. Additionally, to explore the possible influence of genotype on the effects of conditioning, the 5-HTTLPR genotype and other candidate genotypes will be assessed. | — |
Countries
Netherlands
Outcome results
None listed