Narrowing left main artery
Conditions
Interventions
Patients who are scheduled to undergo standard PCI of the left main coronary
artery will be randomized in a 1:1 fashion to the Synergy stent arm or to
XIENCE stent arm. Dual antiplatelet therapy (DA
Sponsors
Golden Jubilee National Hospital, National Times Waiting Board
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patient has an indication for coronary artery revascularisation of the left main artery in accordance with the ESC guidelines 2. Patient has been discussed with the cardiac surgeon prior to PCI procedure 3. Patient is accepted for PCI 4. Patient is at least 18 years of age. 5. The patient understands and accepts the meaning and the aims of the study and is willing to provide written informed consent 6. The patient is willing to comply with specified follow-up evaluation and can be contacted by telephone.
Exclusion criteria
Exclusion criteria: 1. Not able to receive anti-platelet treatment due to contraindications 2. Known allergy to acetylsalicylic acid, clopidogrel, prasugrel or ticagrelor 3. Cardiogenic shock 4. STEMI within the last 5 days 5. Planned surgery within 12 months after stent introduction 6. History of bleeding diathesis or active major bleedings 7. Major surgery within previous 15 days 8. Current participation in another trial which has not yet reached its primary endpoint 9. Life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is MACE rate, including death from any cause, MI, or ischemia-driven target vessel revascularization (TVR) at 2 years after the procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| • The individual events of the primary endpoint • Procedure success (attainment of | — |
Countries
Netherlands
Outcome results
None listed