In vitro Screening of drug candidates against cancer and autoimmune diseases for effects on human blood cells

In vitro Screening of drug candidates against cancer and autoimmune diseases for effects on human blood cells - In vitro screening of new drug candidates

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47365

Enrollment

Registered

2015-07-16

Start date

2015-09-22

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

auto-immune diseases Cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy aged 18-65 years

Exclusion criteria

Exclusion criteria: Not healthy Use of prescription drugs up to 1 week before blood draw

Design outcomes

Primary

Measure	Time frame
Whole blood or purified PBMC will be stimulated in vitro in absence or presence of the drug candidates. The % inhibition of stimulation and frequency of dead cells will be measured. Potent and selective inhibitors will be chosen for further profiling in animal models and ultimately in clinical development.	—

Countries

Netherlands

Outcome results