Alpha-1-antitrypsin deficiency in a diverticular disease population

Alpha-1-antitrypsin deficiency in a diverticular disease population - ALADDIN-study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47360

Enrollment

230

Registered

2016-06-13

Start date

2017-05-30

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diverticulum sac-like protrusion of the colonic wall

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Research group: - Have acute abdominal pain existing more than two hours* and less than five days, - Has a CT-abdomen that shows diverticular disease, - Age above sixty, - Be mentally competent, and - Informed consent.;Control group: - Have acute abdominal pain existing more than two hours* and less than five days, - Has a CT-abdomen that shows no diverticular disease, - Age above sixty, - Be mentally competent, and - Informed consent.

Exclusion criteria

Exclusion criteria: - Does not meet the inclusion criteria - Is mentally incompetent

Design outcomes

Primary

Measure	Time frame
The main exposure factor is any kind of deviations in A1AT	—

Secondary

Measure	Time frame
Secondary exposure factors are: - Concentration of alpha-1-antitrypsin - Inflammation parameters - Risk factors for developing diverticulosis such as * Genetic factors o Family history * Environmental factors: o Low-fiber diet o Obesity o Decreased physical activity o Use of corticosteroids o Use of NSAIDs o Alcohol o Caffeine intake o Cigarette smoking o Polycystic kidney disease * Epidemiological factors o Age o Geography o Life style o Ethnicity Other study parameters Clinical course: - Diverticulitis related hospital admission - Days of hospital admission related to diverticullitis - In need of surgery related to diverticulitis Clinical course: - Inflammation parameters (CRP, leucocytes) during diverticulitis episode - Hinchey score during diverticulitis episode - Complications during diverticulitis episode Since A1AT is also an acute phase protein, this protein can interact with the inflammation process. The concentration of this protein is also affected by cancer, liver disease, pregnancy, estrogen therapy, blood transfusions and intravenous augmentation therapy. This is why genotype analysis needs to confirm the diagnosis.	—

Measure

Time frame

Secondary exposure factors are: - Concentration of alpha-1-antitrypsin - Inflammation parameters - Risk factors for developing diverticulosis such as * Genetic factors o Family history * Environmental factors: o Low-fiber diet o Obesity o Decreased physical activity o Use of corticosteroids o Use of NSAIDs o Alcohol o Caffeine intake o Cigarette smoking o Polycystic kidney disease * Epidemiological factors o Age o Geography o Life style o Ethnicity Other study parameters Clinical course: - Diverticulitis related hospital admission - Days of hospital admission related to diverticullitis - In need of surgery related to diverticulitis Clinical course: - Inflammation parameters (CRP, leucocytes) during diverticulitis episode - Hinchey score during diverticulitis episode - Complications during diverticulitis episode Since A1AT is also an acute phase protein, this protein can interact with the inflammation process. The concentration of this protein is also affected by cancer, liver disease, pregnancy, estrogen therapy, blood transfusions and intravenous augmentation therapy. This is why genotype analysis needs to confirm the diagnosis.

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Countries

Netherlands

Outcome results