Epidemiology and natural history of and risk factors for primary sclerosing cholangitis & primary biliary cirrhosis in the Netherlands

Epidemiology and natural history of and risk factors for primary sclerosing cholangitis & primary biliary cirrhosis in the Netherlands - Epidemiology of PSC/PBC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47329

Enrollment

1100

Registered

2007-04-17

Start date

2007-12-08

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic cholestatic liver disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Established diagnosis of PSC Established diagnosis of PBC age > 18. Resident in the Netherlands.

Exclusion criteria

Exclusion criteria: Inability to give informed consent

Design outcomes

Primary

Measure	Time frame
Primary endpoints: True population-based point-prevalence (2006) and inferred incidence of newly diagnosed cases (2000-2006); natural history with respect to death, liver transplantation, occurrence of cholangiocarcinoma and colorectal carcinoma.	—

Secondary

Measure	Time frame
Secondary endpoints: Odds ratio and relative risk determination of several putative environmental, behavioural and genetic risk factors between PSC and PBC as well as control groups. Among these are smoking behaviuor, previous appendectomy, familial occurrence, previous Chlamydia infection, CCL25 polymorphisms, and the protective effect on the natural history of immunomodulatory medication.	—

Countries

Netherlands

Outcome results