Anxiety Disorder. Panic Disorder
Conditions
Interventions
One of the following:
1. 35% CO2-enriched air inhalation followed by the administration of 40 mg
propranolol.
2. A placebo-inhalation followed by the administration of 40 mg
propranolol.
3. 35
Sponsors
Universiteit van Amsterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: A primary diagnosis of panic disorder according to DSM-V.
Exclusion criteria
Exclusion criteria: * other relevant treatment for panic disorder at the time of study - e.g., CBT * diagnosis of psychosis * use of psychotropic medication * A current state of asthma or COPD, which necessitates medication use * history of respiratory diseases (asthma or COPD in the past does not lead to exclusion) * history of cardiovascular diseases or irregular heartbeat * history of cerebrovascular diseases * history of severe allergic reactions to propranolol, which necessitated hospitalisation * cerebral aneurysm among first-degree relatives * Heart rate 180/100 * epilepsy * any medication contra-indicative of the use of propranolol * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Individual scores on the Panic Disorder Severity Scale. Presence of panic disorder according to DSM V criteria | — |
Secondary
| Measure | Time frame |
|---|---|
| Individual scores on the Panic Appraisal Inventory, Mobility Inventory, Body Sensations Questionnaire, and Agoraphobic Cognitions Questionnaire will be used as secondary study parameters. In addition, willingness to inhale 35% CO2 is used as a secondary study parameter. | — |
Countries
Netherlands
Outcome results
None listed