Serial biomarker AssesMent in adults after percutaneous clOSure of the Atrial septal defect

Serial biomarker AssesMent in adults after percutaneous clOSure of the Atrial septal defect - SAMOSA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47308

Enrollment

Registered

2015-07-17

Start date

2015-07-31

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial septal defect

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Scheduled to undergo percutaneous ASD closure in the Erasmus MC; - Capable of understanding and signing informed consent.

Exclusion criteria

Exclusion criteria: - Patients living abroad or who are not Dutch speaking; - Age 200 umol/L); - Failure of percutaneous ASD closure due to procedural problems.

Design outcomes

Primary

Measure	Time frame
Non-responders after percutaneous ASD closure will be defined as: - Sustained echocardiographic RV dysfunction after one year (eyeballing, right ventricular fractional area change 2.8 m/s).	—

Secondary

Measure	Time frame
The serial evolution of several variables will be investigated, in order to gain more insight in the pathophysiological consequences of volume-load reduction on the right heart: - Biomarkers: NT-proBNP and other biomarkers that may arise to be potentially important during the execution of this study. - Conventional echocardiography: RV dimensions, RV systolic function, LV dimensions, LV systolic and diastolic function; - Speckle tracking echocardiography: global and segmental longitudinal strain of the RV and LV.	—

Measure

Time frame

The serial evolution of several variables will be investigated, in order to gain more insight in the pathophysiological consequences of volume-load reduction on the right heart: - Biomarkers: NT-proBNP and other biomarkers that may arise to be potentially important during the execution of this study. - Conventional echocardiography: RV dimensions, RV systolic function, LV dimensions, LV systolic and diastolic function; - Speckle tracking echocardiography: global and segmental longitudinal strain of the RV and LV.

—

Countries

Netherlands

Outcome results