atherosclerosis hardening of the arteries
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: >= 18 years of age;Additional inclusion criteria for ischemic stroke / TIA patients: - TIA or ischemic stroke in the posterior circulation territory (= supplied via the vertebral and basilar arteries or their branches) - Possibility to perform MRI scanning within 3 months after onset of relevant ischemic symptoms
Exclusion criteria
Exclusion criteria: - Allergic reaction to gadolinium or one of the constituents of its solution for administration - Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body) - Severely impaired renal function (severe renal insufficiency, GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence or absence of intracranial vessel wall abnormalities in arteries of the intracranial posterior circulation. Presence of atherosclerosis is defined as any irregularity of the arterial vessel wall. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Number of vessel wall abnormalities in the intracranial vessel wall MRI scan at 7.0 tesla as compared to 3.0 tesla. - Characteristics of intracranial vessel wall atheroma, by discriminating different MRI signal intensities in the vessel wall atheroma. - The clinical outcome measures (e.g. occurrence of vascular events, level of handicap, current medication) collected during follow-up. | — |
Countries
Netherlands
Outcome results
None listed