GnRH analogues for ovarian stimulation and embryo quality: monitoring embryo development using a time lapse incubator.

GnRH analogues for ovarian stimulation and embryo quality: monitoring embryo development using a time lapse incubator. - GnRH Analogues and Monitoring Embryo Development (GAMED)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47282

Enrollment

Registered

2012-04-23

Start date

2012-08-28

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fertility disorder Subfertility

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Female age = 1.5 ml, concentration: >15*10^6/ml, progressively motile sperm > 32%, so with a VCM >= 7.2) Standard indication for IVF Undergoing first or second IVF cycle

Exclusion criteria

Exclusion criteria: Indication for ICSI Endometriosis Expected poor response One previous IVF treatment not resulting in embryo transfer Medical contra indication for pregnancy or IVF treatment

Design outcomes

Primary

Measure	Time frame
The aim of the study is to analyze the effect of the GnRH analogue used on embryo developmental kinetics. The main study parameter is the time needed from completion of the first cleavage division until reaching the 4-cell stage, determined by retrospective analysis of time lapse recordings.	—

Secondary

Measure	Time frame
Secondary study parameters on embryo developmental kinetics will be the time interval between: - Disappearance of the pronuclei and first cleavage of the embryo, as well as reaching the 2-cell, 4-cell and 8-cell stage; - Completion of first cleavage and reaching the 3-cell and 8-cell stage; - The 3-cell and 4-cell stage. We will also analyze embryo morphology on Day 3 and determine the proportion of good quality embryos, as defined by embryos with 8 cells,	—

Measure

Time frame

Secondary study parameters on embryo developmental kinetics will be the time interval between: - Disappearance of the pronuclei and first cleavage of the embryo, as well as reaching the 2-cell, 4-cell and 8-cell stage; - Completion of first cleavage and reaching the 3-cell and 8-cell stage; - The 3-cell and 4-cell stage. We will also analyze embryo morphology on Day 3 and determine the proportion of good quality embryos, as defined by embryos with 8 cells,

—

Countries

Netherlands

Outcome results