insulin resistance metabolic syndrome
Conditions
Interventions
Patients will be randomised to receive either single allogenous donor feces
(n=12) or single autologous feces (n=12).
bacterial translocation
gut microbiota
metabolic syndrome
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Metabolic syndrome patients: - Caucasian - BMI >25 kg/m2 - At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose *5.6 mmol/l, triglycerides *1.7 mmol/l, waist-circumference >102 cm, HDL-cholesterol 1.04 mmol/l, blood pressure *130/85 mmHg - Scheduled for laparoscopic cholecystectomy or laparoscopic gastric bypass;Lean donors: - BMI 18,5-25 kg/m2
Exclusion criteria
Exclusion criteria: Metabolic syndrome patients: - A history of cardiovascular event (cerebrovascular accident, myocardial infarction or pacemaker implantation) - Use of any medication including proton pump inhibitors and antibiotics in the past three months - (Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate whether an oral fat load induces translocation of intestinal bacteria including Ralstonia picket and whether lean donor fecal transplantation affects this. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate whether changes in (small) intestinal gut microbiota are related to postprandial bacterial translocation. Moreover, we will investigate changes in visceral and subcutaneous adipose tusse and plasma. Furthermore, we will study changes in 24h feces (triglyceride excretion) and 24h urine (TMAO and oxalic acid). | — |
Countries
The Netherlands
Outcome results
None listed