coronary heart disease emphysema lung cancer
Conditions
Interventions
Biomarker
Cardiovascular Diseases
Chronic Obstructive
Imaging
Lung Neoplasms
Pulmonary Disease
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Participants should be 45 years or older, and have completed a lung function test as part of the second Lifelines screening.
Exclusion criteria
Exclusion criteria: -CT of lungs or heart in the previous year -known pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reference values of lung density, bronchial wall thickness, vascular calcification and lung nodules as imaging biomarkers of the Big-3 in the general population aged 45 years and older. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relation of imaging biomarkes of the Big-3 with clinical and laboratory biomarkers. In the BioLife substudy, CT-nodule characteristics and CT-based emphysema scores are correlated to biomarkers based on breath, nasal brush and blood. | — |
Countries
The Netherlands
Outcome results
None listed