Congenital central hypothyroidism plusminus ACTH or growth hormone deficiency: etiology and outcome

Congenital central hypothyroidism plusminus ACTH or growth hormone deficiency: etiology and outcome - CHC in the Netherlands

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47244

Enrollment

170

Registered

2014-07-21

Start date

2017-06-15

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

absent stimulation of thyroid Congenital hypothyroidism of central origin

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Permanent congenital hypothyroidism of central origin detected by the neonatal screening between 1-1-1995 and 1-1-2015.

Exclusion criteria

Exclusion criteria: Transient congenital hypothyroidism of central origin (e.g. due to (untreated) maternal Graves disease).

Design outcomes

Primary

Measure	Time frame
1: Mortality rate 2: Cognitive outcome: school results compared to average CITO test scores and compared to siblings 3: DNA analysis: prevalence of Igsf1 mutations in the subgroup of children with isolated CH-C, results of whole exome sequencing.	—

Countries

Netherlands

Outcome results