Human Brown Adipose Tissue Histological and Mitochondrial Respiratory Analysis

Human Brown Adipose Tissue Histological and Mitochondrial Respiratory Analysis - BAT analysis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47232

Enrollment

180

Registered

2010-03-30

Start date

2010-05-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesitas obesity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients indicated for surgery in the supraclavicular and neck region are included. More specific, patients diagnosed with hyperparathyroidea, struma, benign thyroid gland tumours, implantation of a vagal neurostimulator for epilepsia and cervical neurologic disorders, aged 18-65 years will be included.

Exclusion criteria

Exclusion criteria: Only patients indicated for elective surgery will be included. Patients undergoing acute surgery because of critical illness are excluded. In this patient group informed consent is difficult to obtain and severe inflammation could influence BAT-, WAT- and skeletal muscle responses. Patients with pre-operative mailgn tumours will be excluded.

Design outcomes

Primary

Measure	Time frame
The primary endpoint will be the quantification of mitochondrial respiration in human BAT. Secondary endpoints will be histological protein stainings and mitochondrial content analysis of human BAT. An UCP-1 immunofluorescence assay will be used to detect UCP-1.	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results