brain damage Cerebral Palsy
Conditions
Interventions
For home-based balance training all children with CP will use the X-box One
Kinect (Microsoft). Children will undergo a 6 week training program (5x/week,
30min/session) using Kinect games with a foc
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: * diagnosis of bilateral predominantly spastic CP, with the lower limbs more involved than the upper limbs;* * age range: 7-15 years; * Gross Motor Function Classification System level 2;* * able to stand independently for 2 minutes; * Child and Parent/guardian consent; * Sufficient cooperation & cognitive skills: able to follow simple instructions & complete the measurements. * MRI can be performed without general anesthesia.;* criteria for children with CP specifically, not for the typically developing control children.
Exclusion criteria
Exclusion criteria: * any orthopaedic surgery or other surgical interventions in the past twelve months that might influence mobility; * Botulinum Toxin A injections in the past six months; * Selective dorsal rhizotomy (SDR) in the past year; * Vestibular deficits, benign vertigo or epilepsy; * Claustrophobia; * A pacemaker or other non-removable magnetic metal-containing devices or objects; * Not able to lie still for the duration of the scan; * Not willing to hear about *incidental findings*, potential unforeseen, clinically relevant abnormalities found in the MRI images
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of balance control that will be investigated is the Pediatric Balance Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional (secondary) balance outcomes during standing and walking will be assessed with clinical balance tests (*balance* and *running speed and agility* subtest of the Bruininks-Oseretsky Test of Motor Proficiency, Trunk Control Measurement Scale) and experimental measures during standing and on an instrumented treadmill (kinematic, kinetic and EMG). During standing the Sensory Organization Test will be evaluated to assess the individual`s ability to use visual, proprioceptive and vestibular cues to maintain postural stability in stance, using posturography. During gait, spatiotemporal gait parameters (step width, variability measures, whole body centre-of-mass movement), the Margins of stability, gait sensitivity norm, and Foot Placement Estimator will be included to assess gait stability. Brain neuroimaging data includes structural (T1- weighted/Flair) magnetic resonance imaging (MRI), diffusion tensor imaging, and resting state-fMRI. All measured pre and post training. | — |
Countries
Netherlands
Outcome results
None listed