convulsion epilepsy
Conditions
Interventions
All patients will undergo 3 to 4 paired pulse TMS sessions, over a period of
one year. The first TMS session will take place while the patient is still drug
naïve, the second session 8 to 12 weeks a
Sponsors
Universiteit Twente
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Drug naïve epilepsy patients starting with AEDs * Diagnosis of epilepsy, either generalized or focal * Drug naïve, no prior use of AEDs * Ability to understand and comply with the instructions for the TMS sessions
Exclusion criteria
Exclusion criteria: * Younger than 18 years * Contra-indications of TMS (although not absolute): (possibility of) pregnancy, metal objects in brain/skull, cochlear implant, deep brain stimulator, history of spinal cord surgery, drains in the spinal cord or ventricles, use of seizure threshold lowering medication * Follow-up impossible due to logistical reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters are the characteristics of the MEP (resting motor threshold (rMT) and long intracortical inhibition (LICI)) and TEP (amplitude and latency of peaks). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include additional signal analysis methods applied on the MEP and TEP. For example, wavelet analysis of early and late TEPs and the spatio-temporal characteristics of the TEP. Other study parameters which are documented include: age, gender, handedness, seizure history, type of epilepsy; generalized or focal, type and dose of AEDs, EEG abnormalities (if applicable) and MRI abnormalities (if applicable). | — |
Countries
Netherlands
Outcome results
None listed