parodontitis gingivitis dental decay
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: all participants are 18 years or older cases need an indication to undergo a total tooth extraction. Indication has been made by an oral and maxillofacial surgeon controls: age, smoking- and educational status matched volunteers who respond to poster advertisements
Exclusion criteria
Exclusion criteria: inability to understand verbal and written Dutch or English language participants with (end-stage) liver disease (Child Pugh Class A, B and C) history of chronic auto immune disease (i.e. RA, vasculitis, IBD) use of antiplatelet or antithrombotic medications history of radiation in the head/neck region patients referred for focus detection in order to receive chemotherapy and/or radiotherapy for the treatment of cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Crossectional analysis: difference in coagulation, inflammation and metabolic markers throughout the whole cohort, with PISA as an independent variable Longitudinal analysis: difference in coagulation, inflammation and metabolic markers of patients before and after undergoing a total tooth extraction | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory analysis of the influence of oral mircobiome on the relationships between PISA and primary outcome measures. Our focus will lie in evaluating the quantitative presence of *red complex* bacteria (see Rationale), total bacterial burden and its relationship with PISA and inflammatory/hemostatic status. The goal is to generate hypotheses for further research. | — |
Countries
Netherlands
Outcome results
None listed