Diffusion-weighted MRI in Juvenile Idiopathic Arthritis

Diffusion-weighted MRI in Juvenile Idiopathic Arthritis - DWI in JIA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47139

Enrollment

185

Registered

2012-12-19

Start date

2013-11-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Arthritis Juvenile Idiopathic Arthritis

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Clinically suspected JIA with knee involvement / JIA patients with remitting disease and knee involvement. Scheduled to undergo MRI. Written informed patients (when >12 years of age) and parental consent.;OR;JIA patients with clinically inactive disease for at least 6 months. A history of clinical evident arthritis in at least 1 knee. Scheduled to undergo MRI. Written informed patients (when >12 years of age) and parental consent.

Exclusion criteria

Exclusion criteria: Age

Design outcomes

Primary

Measure	Time frame
The diagnostic accuracy of DWI in the evaluation of disease activity in JIA as compared to contrast-enhanced MRI as the reference standard. The accuracy of DWI in detecting joint inflammation as compared to the physical examination in the evaluation of different stages of disease activity in JIA patients.	—

Secondary

Measure	Time frame
The correlation between DWI and semi-quantitative scores of synovial hypertrophy using the Juvenile Arthritis MRI Scoring (JAMRIS) system (at baseline and at two-year follow-up). The degree of association between DWI parameters and scores obtained from the physical examination (at baseline and at two-year follow-up). The correlation between DWI parameters and laboratory assessments of inflammatory parameters (at baseline and at two-year follow-up). The value of DWI in predicting the clinical course in 1 year time in JIA patients. The responsiveness to change of DWI parameters.	—

Measure

Time frame

The correlation between DWI and semi-quantitative scores of synovial hypertrophy using the Juvenile Arthritis MRI Scoring (JAMRIS) system (at baseline and at two-year follow-up). The degree of association between DWI parameters and scores obtained from the physical examination (at baseline and at two-year follow-up). The correlation between DWI parameters and laboratory assessments of inflammatory parameters (at baseline and at two-year follow-up). The value of DWI in predicting the clinical course in 1 year time in JIA patients. The responsiveness to change of DWI parameters.

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Countries

Netherlands

Outcome results