Afasie en Taalstoornissen in het kader van hersenletsel CVA stroke
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Between 18 * 78 years of age * Ischemic or hemorrhagic cerebral infarction of the left hemisphere * Postonset of > 6 months (chronic stage) * Native speaker of Dutch * Pre-morbidly right handed * Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.
Exclusion criteria
Exclusion criteria: * History of previous stroke * Pre-existent cognitive problems * Severe aphasia (unable to understand instructions or provide consent). This will be operationalised via scores of the Comprehensive Aphasia Test (CAT-NL) or Aachen Aphasia Test (AAT) or Token Test, which are acquired as part of the standard clinical procedure by the co-investigating sites. The following cut-off scores will be used: o CAT-NL, part *Mondeling taalbegrip: zinnen*: C-score >= 5, percentile >= 41 (corresponding to average) o AAT, part *TB-1 Auditief woordbegrip* and *TB-2 Auditief zinsbegrip*: raw score >= 39, corresponding to C-score >= 5, percentile >= 41 o Token Test: raw score >= 37, corresponding to percentile >= 41 * Use of psychotropic medication or recreational drugs * Pregnancy * Serious head trauma * Neurological or psychiatric disorders (other than stroke or epilepsy as a consequence of the stroke) * Intractable epilepsy * Large or ferromagnetic metal parts in the head (except for a dental wire) * Implanted cardiac pacemaker or neurostimulator * Somatic symptom and related disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between electrophysiological activity in the patients* right hemisphere and the integrity of the corpus callosum. | — |
Secondary
| Measure | Time frame |
|---|---|
| The relationship between patients* functional communication abilities and right-hemisphere recruitment, measured through task-related activity and resting-state activity. Other variables that will be included are age, gender, education, and aphasia severity. These measures are routinely gathered as part of the standard clinical work-up at the co-investigating sites. | — |
Countries
Netherlands
Outcome results
None listed