Non-alcoholic fatty liver disease (fatty liver)
Conditions
Interventions
Low fructose diet, where the amount of fructose restriction will be
supplemented by either glucose powder (intervention group) or fructose powder
(control group) (with a minimum of 45 gram/day).
Cardiovascular disease
Fructose
Non-alcoholic fatty liver disease
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age *18 years; - BMI * 28; - Fatty liver index * 60.
Exclusion criteria
Exclusion criteria: - Medical history of liver disease, such as viral and auto-immune hepatitis. - (History of) excessive alcohol consumption (defined as > 2 units/day for women, and > 3 units/day for men); - Use of glucose lowering drugs (including insulin); - Recent illness; - Pregnancy and/or lactation; - Major change in weight and/or physical activity prior to the study; - Contraindications for MRI (i.e. claustrophobia, heart pacemaker or other electronic devices implanted in the body, history of collapse or seizure); - Inability to give informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Markers of cardiovascular risk * i.e. endothelial function, arterial stiffness, plasma lipids, plasma biomarkers of inflammation and endothelial function, and plasma advanced glycation end products * between the intervention and control group. | — |
Primary
| Measure | Time frame |
|---|---|
| Differences in intrahepatic triglyceride content between the intervention and control group. | — |
Countries
The Netherlands
Outcome results
None listed