Long-term safety of preimplantation genetic diagnosis Follow-up of 5 and 8-year old children born after PGD

Long-term safety of preimplantation genetic diagnosis Follow-up of 5 and 8-year old children born after PGD - Follow-up of 5 and 8 -year old children born after PGD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47126

Enrollment

300

Registered

2013-06-21

Start date

2014-01-08

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children born after PGD

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: 5-year old children, singleton or part of twins or triplets, born after either PGD, spontaneous conception after their parents have considered PGD or have undergone prenatal diagnosis (chorionic villus biopsy or amniocentesis) or after IVF/ICSI. At least one of the parents of the children must be willing to participate. Enough competence of the the Dutch language ;8-year old children who have participated in het follow up study at the age of 5

Exclusion criteria

Exclusion criteria: Children with known chromosomal abnormalities or gene disorders

Design outcomes

Primary

Measure	Time frame
Major malformation rate, general health, cognitive and socioemotional development, parent-child interaction and parental stress.	—

Secondary

Measure	Time frame
-most important factors in the decision making process of whether to opt for PGD treatment (for parents of 5 year old children) -the presence of clinically relevant imprinting defects (future study for 5 and 8 year old children) - cardiovascular evaluation (8 year old children)	—

Countries

Netherlands

Outcome results