Coronary microvascular dysfunction dysfunction of the small vessels in the heart
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Stable 1 or 2 vessel ischemic heart disease with at least 1 unobstructed reference coronary artery, where at least 1 coronary artery with a stenosis and 1 reference coronary artery both subtend 10% or more of the left ventricle as estimated by coronary computed tomography angiography (CCTA) * Age at least 18 years * Presence of a segment of at least 3 cm without major side branches proximal to the stenosis and in the reference coronary artery a segment with a length of at least 3 cm without major side branches has to be present
Exclusion criteria
Exclusion criteria: * Pregnancy * Uncorrected severe valvular heart disease * Non-ischemic cardiomyopathy with left ventricular ejection fraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between [15O]H2O PET perfusion imaging MR and invasive MR. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate whether saline infusion and adenosine infusion produce coronary microvascular vasodilation equally. We expect this to be true, and if this is the case, adenosine administration is no longer needed for this measurement. | — |
Countries
Netherlands
Outcome results
None listed