cardiovascular health chronic lung disease in premature babies
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Healthy control group (n30 %.
Exclusion criteria
Exclusion criteria: - Known acquired or congenital hemodynamically significant heart disease (except heart disease as a consequence of pulmonary hypertension) - Pulmonary disorders other than BPD - Kidney disorders - Neurodevelopmental disabilities that would prevent cooperation with CPET and/or CMR imaging. - Absence of written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part A: MR cardiopulmonary exercise protocol validation: The main study parameter is the increase in oxygen consumption of subjects in relation to workload increase during a exercise test on a MR-ergometer and on a conventional ergometer. Part B: CMR exercise study: The main study parameter is stroke volume of the right ventricle. | — |
Secondary
| Measure | Time frame |
|---|---|
| Part A: MR cardiopulmonary exercise protocol validation: Other parameters are maximal heart frequency, CO2 production, respiratory coefficient. Part B: CMR exercise study: Other study parameters are exercise capacity (peak oxygen uptake, VO2max) and several parameters for assessment of lung function (forced expired volume in 1 second, FEV, total lung capacity, TLC, fractional residual capacity, FRC, diffusion capacity for carbon monoxide, DLCO), and assessment of cardiac function and structure (e.g. heart ventricular mass/volume ratio, tricuspid regurgitation velocity, heart ventricular longitudinal strain and ejection fraction). | — |
Countries
Netherlands
Outcome results
None listed