Hypertensie en signalen van sympathische overactiviteit Atrial fibrillation hypertension
Conditions
Interventions
The study population consists of patients with paroxysmal or persistent AF with
out of range hypertension or signs of sympathetic overdrive. Patients will be
randomized into two groups:
Group 1: RDN
Sponsors
Isala Klinieken
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The patient falls within the target group resistent hypertension or sympathic overdrive Patient is an acceptable candidate for renal denervation treatment Patient is
Exclusion criteria
Exclusion criteria: Contraindication to chronic anticoagulation therapy or heparin Previous left heart ablation procedure for AF Acute coronary syndrome, cardiac surgery, PCI or stroke within 3 months prior to enrolment Renal artery stenosis >50% of the arterial lumen, or renal artery lumen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first detection of atrial fibrillation >30 seconds, with the monitoring period starting 3 months after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| - AF burden after 12 months of follow-up, expressed in % of the monitoring period, in patients with continuous rhythm monitoring. The monitoring period starts 3 months after the intervention. - Blood pressure at 3, 6, 12 months after the intervention, and change in blood pressure compared to measurement before the intervention - Blood pressure and heart rate response changes induced by exercise testing - Changes in heart rate variability measures tested by Holter monitoring compared to measurement before the intervention - Changes in arterial stiffness measures post intervention AASI (ambulatory arterial stiffness index) by ambulatory blood pressure monitoring, PWV (pulse wave velocity) and augmentation index compared to measurement before the intervention | — |
Countries
Netherlands
Outcome results
None listed