Reutelen in stervensfase, Ademhalingsstelsel Death rattle noisy breething
Conditions
Interventions
Immediately after starting of the dying phase, and the registration of the
first observations, the patient is administered the study drug: scopolamine 1
ml s.c. (= 20 mg) or placebo 1 ml s.c..
This
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Admission for care and treatment in one of the participating hospice facilities 2. It is known by the patient and his/her relatives that the admission will be up to death 3. At admission life expectancy is at least 3 days 4. At explanation of the study (shortly after admission to hospice facility) and signing of the informed consent the patient is conscious 5. Presence of a signed informed consent
Exclusion criteria
Exclusion criteria: 1. There are signs of a respiratory infection (upper or lower respiratory tract) 2. The patient has a tracheostomy or tracheocanula 3. The patient uses an anticholinergic or octreotide 4. At the start/At recognition of the dying phase death rattle is present at grade 1 or more, according to Back
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of patients who develop death rattle, defined as the appearance of grade 2 or higher according to the method of Back measured at 2 successive times/time points with an interval of 4 hours. The following degrees of rattle are distinguished: grade 0 = no audible rattle grade 1 = rattle only audible close to the patient grade 2 = rattle in a quiet room clearly audible at the foot of the bed grade 3 = rattle in a quiet room audible at a distance of 10 meters (at the door of a room) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Time from recognition of the dying phase until death rattle - Appearance of the adverse events micturition, dry mouth and restlessness by observations noted in the digital Care plan of the dying (formerly known as Liverpool Care Pathway) - Quality of life during the last three days of the life of the patient, according to the caregiver, indicated by a numerical value on a scale of 0 to 10 (0 = no quality; 10 = the best quality that can be imagined) - Quality of dying of the patient, according to the caregiver, indicated by a numerical value on a scale of 0 to 10 (0 =no quality; 10 = the best quality that can be imagined ) - Manner of death, according to the caregiver, indicated with 15 qualitative terms. - Moment of death, according to the caregiver, indicated with 15 qualitative terms. - Quality of Life in the last three days of the patient according to the relatives, indicated with a numerical value on a scale of 0 to 10 (0 =no quality; 10 = the best quality that can be imagined ) - Quality of dying of the patient, indicated by the relatives, indicated with a numerical value on a scale of 0 to 10 (0 = no quality; 10 = the best quality that can be imagined ) - The way of dying, according to the relatives, indicated with 15 qualitative terms. - Moment of death, according to the relatives, indicated with 15 qualitative terms. - Extent of bereavement for relatives according to the Leiden Score (15) - Experience of participating in a (double-blind, placebo-controlled) scientific research trial through a questionnaire and interviews with questions about the perception and the meaning of participating in a trial indicated by a numerical value on a scale of 1 to 4 (1 = no stress; 4 = extremely stressful) | — |
Countries
Netherlands
Outcome results
None listed