Microcirculatory perfusion alterations in severe burn injury

Microcirculatory perfusion alterations in severe burn injury - MIPA trial

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47089

Enrollment

Registered

2017-09-15

Start date

2018-11-12

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

burns fluid resuscitation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: burns TBSA>15% (total body surface area)

Exclusion criteria

Exclusion criteria: no informed consent suspected serious infection

Design outcomes

Primary

Measure	Time frame
Main study parameters/endpoints: Standard operating procedure for measurement of microcirculatory perfusion (sublingual tissues): vessel density parameters, microvascular flow index and flow heterogeneity will be measured on admission (T=0) and after 4, 8, 12 and 24 hours.	—

Secondary

Measure	Time frame
Skin perfusion maps (Laser Speckle Imaging) will be recorded. Skin perfusion maps will be displayed in unaffected skin and wounds of different burn depth. (2nd and 3rd degree burn depth) on predetermined different times. Blood and urine samples: Blood and urine samples will be collected at the certain time points to be analysed for syndecan, hyaluronic acid, heparin sulfate, MDA, free-Hb and Ni/Na	—

Measure

Time frame

Skin perfusion maps (Laser Speckle Imaging) will be recorded. Skin perfusion maps will be displayed in unaffected skin and wounds of different burn depth. (2nd and 3rd degree burn depth) on predetermined different times. Blood and urine samples: Blood and urine samples will be collected at the certain time points to be analysed for syndecan, hyaluronic acid, heparin sulfate, MDA, free-Hb and Ni/Na

—

Countries

Netherlands

Outcome results