Blood-Brain Barrier function: The key to successful cognitive aging?

Blood-Brain Barrier function: The key to successful cognitive aging? - Blood-Brain Barrier function and cognitive aging.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47086

Enrollment

Registered

2017-03-01

Start date

2017-05-22

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

age-related decline in mental ability. Blood-Brain Barrier leakage

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Informed consent before participation - Participation in 12-year follow-up of the MAastricht Aging Study - Mini-Mental State Examination score >= 25 - Disability Assessment for Dementia score > 90%

Exclusion criteria

Exclusion criteria: - Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos) - Contraindications for the gadolinium-containing contrast agent (renal failure) as determined by the estimated Glomerular Filtration Rate

Design outcomes

Primary

Measure	Time frame
- Episodic memory: Verbal Learning Test, delayed recall - Hippocampal volume - Blood-Brain Barrier leakage	—

Secondary

Measure	Time frame
Other measures of cognitive performance ( for post-hoc analyses): - Learning: Verbal Learning Test, immediate recall - Basic processing speed: Letter-Digit Substitution Test - Complex information processing: Stroop Color-Word Test - Global cognition: Mini-Mental State Examination Other measures of radiologically visible brain tissue abnormalities (for post-hoc analyses): - Cortical atrophy - White Matter Hyperintensities - Small cortical infarcts - Lacunes - Microbleeds - Enlarged perivascular spaces - White matter integrity	—

Measure

Time frame

Other measures of cognitive performance ( for post-hoc analyses): - Learning: Verbal Learning Test, immediate recall - Basic processing speed: Letter-Digit Substitution Test - Complex information processing: Stroop Color-Word Test - Global cognition: Mini-Mental State Examination Other measures of radiologically visible brain tissue abnormalities (for post-hoc analyses): - Cortical atrophy - White Matter Hyperintensities - Small cortical infarcts - Lacunes - Microbleeds - Enlarged perivascular spaces - White matter integrity

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Countries

Netherlands

Outcome results