Vessel wall imaging in moymoya vasculopathy using intracranial MRI at 7.0 tesla

Vessel wall imaging in moymoya vasculopathy using intracranial MRI at 7.0 tesla - The 7T-moyamoya study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47058

Enrollment

Registered

2014-09-10

Start date

2015-08-14

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moyamoya puff of smoke

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for pediatric patients - Moyamoya vasculopathy - Signed informed consent - Age 12-18 yrs old - MRI without anesthesia;Inclusion criteria for adult patients - Moyamoya vasculopathy - Signed informed consent - Age 18-55 yrs old - Legally competent - MRI without anesthesia;Inclusion criteria for control subjects - 12-60yrs old - 7T MR imaging performed for suspected pituitary adenoma - No known intracranial vessel wall disease or history of cerebrovascular events If applicable: - Legally competent - Signed informed consent - MRI without anesthesia

Exclusion criteria

Exclusion criteria: For patients - Allergic to gadolinium - Impaired renal function (severe renal insufficiency, GFR

Design outcomes

Primary

Measure	Time frame
The intracranial vessel wall (circle of Willis and its main branches and the moyamoya vessels) characteristics in MMV.	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints Establishing differences (e.g. in presence or absence of intracranial vessel wall abnormalities) in the vessel walls between the symptomatic and asymptomatic hemisphere in each individual patient and between children and adults. Third study parameters/endpoints The investigation of blood flow through the major arteries (circle of Willis and its main branches) and the moyamoya vessels (lenticulostriatal and leptomeningeal collaterals). Other study parameters The characterization the intracranial vessel wall, by evaluating the signal characteristics on multiple MRI sequences.	—

Measure

Time frame

Secondary study parameters/endpoints Establishing differences (e.g. in presence or absence of intracranial vessel wall abnormalities) in the vessel walls between the symptomatic and asymptomatic hemisphere in each individual patient and between children and adults. Third study parameters/endpoints The investigation of blood flow through the major arteries (circle of Willis and its main branches) and the moyamoya vessels (lenticulostriatal and leptomeningeal collaterals). Other study parameters The characterization the intracranial vessel wall, by evaluating the signal characteristics on multiple MRI sequences.

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Countries

Netherlands

Outcome results