The role of medial prefrontal schema processing and sleep for memory bias in major depression

The role of medial prefrontal schema processing and sleep for memory bias in major depression - Schema, Sleep and Depression

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47044

Enrollment

Registered

2019-08-27

Start date

2018-02-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurowetenschappelijk onderzoek depression mood

Interventions

Depression

Memory

Schema

Sleep

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: For patients: * Males and females between 25-55 years of age * Patients with an official diagnosed of unipolar major depressive disorder, without psychotic features (as defined by DSM-IV-TR) * On antidepressant medication (SSRIs) for at least 2 weeks and a Hamilton score between at least 17 and 30.;For controls: Males and females between 25-55 years of age

Exclusion criteria

Exclusion criteria: * Presence of a current or past relevant somatic disorder * Presence of comorbid bipolar disorder, schizophrenia or substance abuse disorder * MRI-related exclusion criteria (i.e. claustrophobia, pregnancy, internal metal objects, etc.) * Impossibility to obtain a valid informed consent A control group matched for age and sex will be recruited. Exclusion criteria for the control group will be similar to the exclusion criteria for the treatment group, with the following additions: * No current or past psychiatric illness

Design outcomes

Primary

Measure	Time frame
The primary aim of this project is to test the hypothesis that in patients suffering from MDD, an mPFC-related presence of negatively toned memory schemas and its interactions with the amygdala contributes to a preferential encoding and subsequent REM sleep-related consolidation of negative stimuli, thus developing and perpetuating a negative memory bias. As a neurocognitive measure of (valence specific-) schema memory, we will investigate the performance on the false memory recall and recognition task (the remembering of related but never presented words i.e. false alarms) and its neural correlates. Here, we aim to investigate the underlying neural mechanisms (mPFC/ amygdala activity and connectivity) during both encoding and retrieval and relate these to sleep parameters (amount REM, eye movement, power differences per group. Furthermore, SSRIs are known to suppress REM sleep differently depending on acute or chronic intake (Wilson and Argyropoulos, 2005). We therefore aim for disentangling the REM suppressing and non REM suppressing side effects of the prescribed medication and its effects on the memory task, These measures combined will provide us the opportunity to explore the tight relations between schema memory, memory bias, (REM) sleep and depression in detail.	—

Measure

Time frame

The primary aim of this project is to test the hypothesis that in patients suffering from MDD, an mPFC-related presence of negatively toned memory schemas and its interactions with the amygdala contributes to a preferential encoding and subsequent REM sleep-related consolidation of negative stimuli, thus developing and perpetuating a negative memory bias. As a neurocognitive measure of (valence specific-) schema memory, we will investigate the performance on the false memory recall and recognition task (the remembering of related but never presented words i.e. false alarms) and its neural correlates. Here, we aim to investigate the underlying neural mechanisms (mPFC/ amygdala activity and connectivity) during both encoding and retrieval and relate these to sleep parameters (amount REM, eye movement, power differences per group. Furthermore, SSRIs are known to suppress REM sleep differently depending on acute or chronic intake (Wilson and Argyropoulos, 2005). We therefore aim for disentangling the REM suppressing and non REM suppressing side effects of the prescribed medication and its effects on the memory task, These measures combined will provide us the opportunity to explore the tight relations between schema memory, memory bias, (REM) sleep and depression in detail.

—

Secondary

Measure	Time frame
Additionally, we aim to examine the effect of group on mPFC/ amygdala and whole brain post-encoding resting-state connectivity. Using exploratory correlational analyses, we want to test for altered mPFC interactions with the amygdala in particular. We expect these interactions to be augmented in participants suffering from depression and that these interactions are related to enhanced negative false memory persistence and decreased positive memory persistence.	—

Measure

Time frame

Additionally, we aim to examine the effect of group on mPFC/ amygdala and whole brain post-encoding resting-state connectivity. Using exploratory correlational analyses, we want to test for altered mPFC interactions with the amygdala in particular. We expect these interactions to be augmented in participants suffering from depression and that these interactions are related to enhanced negative false memory persistence and decreased positive memory persistence.

—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)