Mood Disorders in Elderly and ECT (Electroconvulsive therapy): Electroconvulsive therapy can induce brain derived neurotrophic factor in serum and increase cortisol levels to enhance neurorestorement of hippocampal volume and function.

Mood Disorders in Elderly and ECT (Electroconvulsive therapy): Electroconvulsive therapy can induce brain derived neurotrophic factor in serum and increase cortisol levels to enhance neurorestorement of hippocampal volume and function. - MODECT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47034

Enrollment

Registered

2010-09-14

Start date

2011-01-25

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychotic depression severe depression

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: severe depression conform DSM IV criteria egible for electroconvulsive therapy, inpatient, 60 years and older

Exclusion criteria

Exclusion criteria: dementia, younger than 60 years severe neurological disorder incapacity to give informed consent

Design outcomes

Primary

Measure	Time frame
clinical parameters predict safety and effect of ECT MRI findings predict safety and effect of ECT lack of cortisol response predicts response to ECT BDNF increases after ECT and there is neurorestorement of hippocampal volume genetic profile predicts clinical parameters and effect of ECT	—

Secondary

Measure	Time frame
there are no secundary study parameters	—

Countries

Netherlands

Outcome results