Alzheimer desease dementia
Conditions
Interventions
dementia
neurodegeneration
pain
Sponsors
Huisartsgeneeskunde
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria:;All subjects: - Age from 55 * 85 yr - Willingness to cooperate and sign written informed consent * or proxy consent with assent of participating subject;Normal Healthy Controls (CP): - MMSE scores between 27-30 - Without subjective memory complaints;Alzheimers*s disease dementia (AD): - Diagnosis of probable AD according to the Alzheimer*s disease and Related Disorders Associations (NINCDS-ADRDA) criteria and NIA-AA guidelines ( McKhann et al. 2011).;Frontotemporal dementia (FTD): - Diagnosis of behavioral variant FTD (FTD-b) according to the revised consensus criteria (Rascovsky et al. 2011). - Diagnosis of a subtype of FTD of Primary Progressive Aphasia (PPA), divided into Semantic Dementia (SD), Progressive Nonfluent Aphasia (PNFA) and LPA due to FTD (Gorno-Tempini et al. 2011). ;Vascular dementia (VD): - Diagnosis of probable VD according to the NINDS-AIREN (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l*Enseignement en Neurosciences) guidelines (Roman et al. 1993).
Exclusion criteria
Exclusion criteria: All subjects: - History of major psychiatric illness - Medications which may affect pain processing (selective serotonin re-uptake inhibitors, opioids, other analgesics) - Contraindications for MR-measurements (e.g. cochlear implants and most permanent pacemakers, red tattoos);Normal healthy Controls: - abnormal results on neuropsychological tests - subjective memory complaints;All patients: - Cognitive deficits could be explained by non-neurodegenerative condition (e.g. stroke, neoplasm, head injury, hydrocephalus or other medical condition)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to various mild pain stimuli (pressure pain will be applied to the shoulder and temperature (heat) will be applied to the forearm ) - Self -report - Facial expression (the face will be videotaped and analyzed using the Facial Action Coding System) - Heartrate and heartrate-variability | — |
Secondary
| Measure | Time frame |
|---|---|
| - structural MRI (grey and white matter (especially in frontal areas)) - Neuropsychology testing (attention, memory, executive functioning) | — |
Countries
The Netherlands
Outcome results
None listed