Major Depressive Disorder recurrent type
Conditions
Interventions
A&B. none
C, D, E. CCT (21 sessions of the Paced Auditory Serial Addition Task (PASAT)
1/day), sham CCT (21 sessions of the Peripheral Visual Training (PVT), ABM (42
sessions 2/day
positive bias training) or sham ABM (42 sessions 2/day
no
bias training), or MBT (21 days, 8 prompts/day
in 5x participants will be
asked to recall, evaluate and describe a recent positive event) or sham MBT (21
days, 8 prompts/day
in 5x participants will be asked to describe and evaluate
their current location).
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a patient must meet all of the following criteria: - recurrent MDD diagnoses (assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) (SCID) [First 1996]) - at least 3 previous MDD-episodes (as assessed with the SCID-interview) - a 17-item Hamilton Depression Rating Scale (HDRS17) =8 weeks) - age 18-65 years - in possession of smartphone and experienced in use thereof For the focus-groups in WP1, assessment of unipolarity, number of recurrences and non-depressed state will be assessed by history only (no SCID/HDRS17) as more thorough assessments are not proportional to the aim of the focus-groups.
Exclusion criteria
Exclusion criteria: For both WPs: - diagnosis of bipolar, primary psychotic or borderline personality disorder or strong suspicion of this type of disorder - primary diagnosis of substance use or anxiety disorder with secondary MDD (comorbid secondary anxiety disorder allowed for participation) - electroconvulsive therapy within two months before inclusion - average alcohol intake of >3 units/day - daily use of benzodiazepines (>=5mg diazepam or equivalent) - Incompatible smartphone to install BeHapp ;Additional exclusion-criteria for WP2: - ongoing psychotherapy during the CCT/ABM training - previous CCT/ABM ;For the add-on MRI-part of WP2, standard MRI exclusion criteria will apply: - Metal objects in the body - Claustrophobia - A history of head trauma or neurological disease, severe general physical illness
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| B, E. Changes in ESM-based symptom-networks; C, D. Drop-out/noncompliance ( | — |
Primary
| Measure | Time frame |
|---|---|
| A. Saturation of ideas obtained in the focus-groups; B, E. SCID-+ve recurrences of depression during follow-up; C, D. Changes in PASAT, Visual Probe and Recall/Evaluation task (RET) performance | — |
Countries
Netherlands
Outcome results
None listed