breast cancer breast malignancy
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Female gender; - *18 years old; - Patients with cTis-4N0-3M0-1 breast cancer (before any treatment) or with pTis-4N0-3M0-1 breast cancer (postoperatively); - Written informed consent provided.;Additional inclusion criterion for the MRI regional lymph nodes imaging arm and RT planning CT scan: - Positive lymph nodes based on standard diagnostic ultrasound-guided fine needle aspiration. - Tumor positive axillary lymph nodes on standard diagnostic FDG-PET scan: o For preoperative study participation: on FDG-PET scan before start of any treatment; o For postoperative study participation: on FDG-PET after neoadjuvant systemic therapy if neoadjuvant systemic therapy was given.
Exclusion criteria
Exclusion criteria: - Legal incapacity; - MRI exclusion criteria of the MRI safety group of Radiology (UMC Utrecht); - Previously known inability to undergo the scanning procedure.;Additional exclusion criterion for patients in the regional lymph nodes imaging arm: - Previous ALND and/or surgery of the supraclavicular region.;Additional exclusion criterion for patients in the breast imaging arm: - Breast tumor > 3 cm; - For postoperative study participation: large seroma volume during physical examination and/or on standard RT planning CT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Develop optimal MRI-sequences and an on-line adaptive MRI-only treatment planning workflow. 2) Investigate the feasibility of delineating tumor positive lymph nodes on MRI registered with the standard diagnostic FDG-PET scan and standard RT planning CT scan, compared to delineation based on standard RT planning CT scan and standard diagnostic FDG-PET scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed