The microbiome and the chance of recurrent venous thrombosis determined by the DASH-score (MIDAS-study)

The microbiome and the chance of recurrent venous thrombosis determined by the DASH-score (MIDAS-study) - MIDAS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON47000

Enrollment

Registered

2015-10-27

Start date

2016-05-13

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parodontitis deep vein thrombosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - 18 years of age or older - First idiopathic or oral contraceptive use-associated deep vein thrombosis of the leg or idiopathic pulmonary embolism - No further or other indication to continue anticoagulant therapy - Understand spoken and written Norwegian or Dutch or English. - Able to give written informed consent

Exclusion criteria

Exclusion criteria: - Liver failure - Clinical active infection or auto-immune disease - Pregnancy or puerperium

Design outcomes

Primary

Measure	Time frame
Any differences between cases (DASH score >1) and controls (DASH	—

Secondary

Measure	Time frame
- Determine associations between pathologic changes in the microbiome with factor VIII:C, D-dimer, clot lysis time and the endogenous thrombin potential - Determine associations between pathologic changes in the microbiome and complement activation - Determine associations between pathologic changes in the microbiome with AGEs - Determine associations between severity of periodontitis (expressed through PISA) and risk of recurrent venous thrombotic events.	—

Measure

Time frame

- Determine associations between pathologic changes in the microbiome with factor VIII:C, D-dimer, clot lysis time and the endogenous thrombin potential - Determine associations between pathologic changes in the microbiome and complement activation - Determine associations between pathologic changes in the microbiome with AGEs - Determine associations between severity of periodontitis (expressed through PISA) and risk of recurrent venous thrombotic events.

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Countries

Netherlands

Outcome results