A study to compare function and phenotype of bone marrow and circulating immune cells of healthy control subjects to vascular patients

A study to compare function and phenotype of bone marrow and circulating immune cells of healthy control subjects to vascular patients - ACCESS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46975

Enrollment

Registered

2016-02-17

Start date

2017-02-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart attack myocardial infarction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age: >34 years old (mean age 57 years) - Gender: subjects of either gender (85% male) - BMI between 18 and 33 kg/m2

Exclusion criteria

Exclusion criteria: - Clinically evidence or at increased risk for cardiovascular disease or diabetes - Clinically evidence for chronic inflammation - Use of any cardiovascular medication, including but not limited to lipid-lowering therapy, antihypertensive drugs, antidiabetic drugs, platelet aggregation inhibitors and anticoagulants - Any other known systemic disorder such as hepatic, renal, hematologic, and malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.

Design outcomes

Primary

Measure	Time frame
The primary study parameter is GM-CFU of bone marrow HSPCs (=function)	—

Secondary

Measure	Time frame
The secundary study parameter is flow cytometry of HSPCs (=phenotype) from bone marrow and blood	—

Countries

Netherlands

Outcome results