T-cell turnover during HIV infection; production and life span of T-cells in HIV infected individuals during cART

T-cell turnover during HIV infection; production and life span of T-cells in HIV infected individuals during cART - T-cell turnover during HAART: the CTRL-ALT-DEL study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON46926

Enrollment

Registered

2010-11-30

Start date

2011-05-17

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS seropositive

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All groups: -All study subjects have to be adults (18 years of age, or older) and sound of mind and judgement. Study group: -They have to be HIV-1 infected and treated with cART. -They have to have a long-term undetectable viral load (= HIV RNA , 50 copies/ml blood) -The number of CD4 T-cells should have increased to at least 350 cells per microliter blood. Control group low CD4 T-cells during cART: -They have to be HIV-1 infected and treated with cART. -They have to have a long-term undetectable viral load (= HIV RNA , 50 copies/ml blood) -The number of CD4 T-cells should be less than 350 cells per microliter blood. Control group HIV-1 infected, high CD4 T-cell numbers without cART -They have to be HIV-1 infected. -The number of CD4 T-cells should be more than 350 cells per microliter blood.

Exclusion criteria

Exclusion criteria: -HIV-2 infection -Participants may nog have an active infection for which anti microbial drugs are being used -Participants may not have an active hepatitis B or C infection -Chronic hepatisis B or C for which treatment with (peg)interferon and/or ribavirine (Note: patients with untreated chronic hepatitis B or C can be included) -They may not use immune suppressive ot immune modulating medication -Radiotherapy or chemotherapy in the past 2 years -Pregnancy or breastfeeding an infant -Participation in other studies

Design outcomes

Primary

Measure	Time frame
The most important study parameter is the lifespan of T-cells in HIV-1 infected individuals that reconstitute their CD4 T-cell numbers well, compared to HIV-1 infected individuals that do not.	—

Secondary

Measure	Time frame
A difference in T-cell origin between immunological responders and non-responders A difference in source of the T-cells between immunological responders and non-responders	—

Countries

Netherlands

Outcome results