MR-sequence optimization and workflow development for treatment guidance, using the integrated MR scanner of the MR-Linac system. Towards MR-guided adaptive radiation therapy.

MR-sequence optimization and workflow development for treatment guidance, using the integrated MR scanner of the MR-Linac system. Towards MR-guided adaptive radiation therapy. - Development of MR-guided radiotherapy.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON46910

Enrollment

190

Registered

2017-02-09

Start date

2017-07-12

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer tumour

Interventions

Patients will undergo an MRI exam up to a maximum of 5 times. The scan duration will be approximately 30 minutes per exam, during which multiple sequences can be scanned. The MRI exams will include

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with histologically proven carcinoma of the prostate, rectum, esophagus, lung, breast, head and neck, gastric-, bladder- anal and gynaecological cancer, liver-, lung- and soft tissue oligo-metastases (adrenal glands, abdominal lymph nodes), brain tumors and sarcoma patients will be included.

Exclusion criteria

Exclusion criteria: Contra*indications for a MRI examination Patients with previous allergic reaction to infusion of contrast media (Gadolinium-based) Patients with WHO performance status >2 Claustrophobia Patients >140 kg and/or a body with > 60 cm

Design outcomes

Primary

Measure	Time frame
To optimize MR-sequence protocols for MR-guided radiotherapy, using the integrated Phillips MRI scanner of the MRL system	—

Secondary

Measure	Time frame
• Demonstrate the feasibility of acquiring clinically usable images with clear visualization of the tumor and organs at risk (OAR) for image guidance with the MRI scanner integrated in the MRL system. • Selection of optimum imaging sequences for image-registration and (auto)contouring of the tumor and OAR for adaptive re-planning. • To monitor changes in target volume, target position and inter-/intra-fraction motion of the tumor and OAR during radiotherapy with serial MR images, to establish the need of adaptive re-planning during the course of treatment on an MRL. • To establish an estimate on the variation in functional MRI parameters during radiation therapy. • To develop an optimal MRL workflow for online MRI-guided adaptive radiotherapy.	—

Measure

Time frame

• Demonstrate the feasibility of acquiring clinically usable images with clear visualization of the tumor and organs at risk (OAR) for image guidance with the MRI scanner integrated in the MRL system. • Selection of optimum imaging sequences for image-registration and (auto)contouring of the tumor and OAR for adaptive re-planning. • To monitor changes in target volume, target position and inter-/intra-fraction motion of the tumor and OAR during radiotherapy with serial MR images, to establish the need of adaptive re-planning during the course of treatment on an MRL. • To establish an estimate on the variation in functional MRI parameters during radiation therapy. • To develop an optimal MRL workflow for online MRI-guided adaptive radiotherapy.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)